Prof. Dr. Cleydson Breno and Dr. Mark Kimani from the Federal University of Amapá, Braziland the University of Embu, Kenya, respectively have joined forces in a collaborative effort.
THEIR MISSION?
a) Search for potential drugs through chembioinformatics approach – a powerful approach that integrates chemistry, biology and computer science for drug discovery research.
b) Motivate young researchers to delve into the rich biodiversity of their regions, searching for hidden bioactive compounds with potential therapeutic applications.
c) Equip upcoming scientists with the valuable skills in chemobioinformatics Techniques
Their exciting initiative has so far yielded the following chemical databases:
1. Naturally Occurring Ent-kaurane Diterpenoids Database: This valuable resource catalogs a diverse range of entkaurane diterpenoids, a fascinating class of organic compounds. Ent-kaurane diterpenoids are known for their impressive biological activities, making them promising candidates for drug discovery. For detailed information about this interesting class of compounds see https://doi.org/10.3390/ph17040510.
2. Zanthoxylum Compound Database: This specialized database focuses on the unique chemical profile of the Zanthoxylum genus. Zanthoxylum plants have been used in traditional medicine for centuries, and this database unlocks a wealth of information about the pharmaceutical potential of its phtyochemicals. See https://doi.org/10.1016/j.sajb.2023.09.009 for further details.
3. Croton Species Phytochemicals Database: This database delves into the chemical makeup of Croton species, plants known for their abundance of secondary metabolites, such as diterpenes, triterpenes, alkaloids, and flavonoids. These compounds exhibit a wide range of biological activities, including antimicrobial, anti-inflammatory, antioxidant, and anticancer properties. See xxx for further details. (DOI will be added soon)
4. Vernonia Species Compounds Database: This resource sheds light on the rich tapestry of compounds found within the Vernonia genus. These plants are a treasure trove of bioactive natural products with promising applications in drug discovery. See xxx for further details. (DOI will be added soon)
5. Vepris Genus Compound Database: This database expands our knowledge base by exploring the chemical composition of Vepris species. Plants in this genus are known for their diverse chemical profiles, including a range of unique alkaloids with potential applications in drug development. See https://doi.org/10.1016/j.sajb.2023.03.057 for further details.